• br DMSO D O and the

  2020-08-07

  

   DMSO:D2O (3:2) and the stability in these solutions was higher (4 days). Both Titanocref (2) and Titanofin (4) are soluble in DMSO:PBS (1:99) in the micromolar range (necessary for the biological assays). 2.2. Cytotoxicity, selectivity, cell death and BAY-598 arrest The cytotoxicity of t

• br Pereira D M Correia da Silva G Valent

  2020-08-07

  

  Pereira, D.M., Correia-da-Silva, G., Valentão, P., Teixeira, N., Andrade, P.B, 2014b. GC–MS lipidomic profiling of the echinoderm Marthasterias glacialis and screening for activity against human cancer and non-cancer cell lines. Comb. Chem. High Throughput Screen 17, 450–457. Contents lists ava

• br Genotype analysis br PARK promoter

  2020-08-06

  

  2.3. Genotype analysis PARK2 promoter variants rs2276201 and rs9347683 were selected for genotyping. These two SNPs were analyzed using Polymerase chain reaction – restriction fragment length polymorphism (PCR-RFLP) assay. Primer sequences used for PCR, product size, restriction endonucleases (

• br References br Sheetz KH

  2020-08-06

  

  References 1. Sheetz KH, Derstine B, Englesbe MJ. Propensity scores for compara-tive effectiveness research: finding the right match. Surgery. 2016;160:1425–1426. 2. Auffenberg GB, Lane BR, Linsell S, Cher ML, Miller DC. Practice- vs physician-level variation in use of active surveillance fo

• br Lung squamous cell carcinoma Bladder transitional

  2020-08-06

  

  Lung squamous cell carcinoma; Bladder transitional cell carcinoma 8 52 p.R4400Q Missense COSM5453041 Breast lobular carcinoma; Colon adenocarcinoma [33] 9 52 p.E4378K Missense COSM4943274 ER-positive breast carcinoma; Bladder transitional cell carcinoma [33,44] COSMIC, the Cat

• br General procedure for urea synthesis from

  2020-08-04

  

  5.1.2. General procedure for urea synthesis from isocyanates The appropriately substituted aryl isocyanate (1.40 mmol) was added to a suspension of amine 13a (1.33 mmol) in anhydrous tetra-hydrofuran (15 mL) under a nitrogen atmosphere. The mixture was stirred at room temperature for 4 h and th

• br Apoptosis assay br T

  2020-08-04

  

  2.5. Apoptosis assay 4T1 cells were cultured in the presence or absence of ART (100 μM) for 48 h in 96-well plates at a concentration of 1 × 106 cells/mL. To detect apoptosis, the cells were stained using an Annexin-V Apoptosis Detection kit I (BD Biosciences) and subsequently evaluated by flow

• br that the mice were divided into six

  2020-08-03

  

  that, the mice were divided into six groups and treated respectively as we described previously (Fig. 3). 3.4. Inhibition of lymphatic metastasis by lymphatic chemotherapy Abundant lymphatic vessels are located in the footpad of nude mouse, which form unidirectional lymphatic drainage. Thus,

• Echinomycin br This study used breast cancer

  2020-08-02

  

  This study used breast cancer cell lines the MCF-7 as the experi-mental cancer Echinomycin (ATCC No: HTB-22™), and VERO cell line (ATCC® No: CCL-81™) as a control cell line. These cells were obtained from American type Collection Culture. Frozen cells were thawed and in-oculated into 5 mL of Dulbe

• br mitochondrial anti apoptotic protein Bcl in a dose depend

  2020-07-31

  

  mitochondrial anti-apoptotic protein Bcl-2 in a dose-dependent manner (Fig. 7a). Compared with the experimental group, the protein level of Bcl-2 was significantly down-regulated after the exposure to 5-FU. In addition, the protein level of Bax was gradually up-regulated with the intervention of C

• br mechanism is still unknown AAMP expression is

  2020-07-29

  

  mechanism is still unknown [12]. AAMP expression is increased in a number of cancer Fluxametamide like invasive gastrointestinal and breast carci-noma cells; it is considered a marker of poor prognosis [13,14]. The epidermal growth factor receptor (EGFR), which is anchored in the cytoplasmic memb

• br more toxic products triene conjugates

  2020-07-28

  

  more toxic products (triene conjugates, Schiff bases), which is con-firmed by the corresponding correlation coefficients (Table 5). It should also be noted that for MDA, the correlation coefficients in normal and in cancer pathology have different signs. Normally, an increase in the intensity of the Jas

• br ACCEPTED MANUSCRIPT br Subgroup analysis br As

  2020-07-28

  

  ACCEPTED MANUSCRIPT Subgroup analysis As the therapeutic indications for ERCP are more common in biliary strictures and published data show differences in diagnostic sensitivity according to location, we next analyzed the data separating biliary and pancreatic malignant samples. Sensitivity

• br We have recently shown

  2020-07-27

  

  We have recently shown that incorporation of a thiazole-or-ange-20-deoxyuridine conjugate, dUTO, 1 (Fig. 1) into an oligonu-cleotide probe targeting cyclin D1 mRNA (a breast cancer marker) allowed the sensitive detection of the target based on a 7-fold enhanced fluorescence of the probe. Fluoresce

• br Grant Support This work was supported in part by

  2020-07-27

  

  1 Grant Support: This work was supported in part by Grant CP120017 from the Cancer Prevention and Research Institute of Texas to Asuragen (PI: G.J.L.), by the National Institute of Environmental Health Sciences of the National Institutes of Health under award number R43ES024365 (PI: B.C.H.), and b

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