• br Recently increasing attention has been paid to the

  2020-08-30

  

  Recently, increasing attention has been paid to the presence of specific and strongly over-expressed receptors, notably the epidermal growth factor receptor (EGFR), on the surface of cells of many cancer types including NSCLC [7]. The EGFR plays a key role in signalling Corresponding authors.

• br QUANTIFICATION AND STATISTICAL ANALYSIS br Data are prese

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  QUANTIFICATION AND STATISTICAL ANALYSIS Data are presented as mean ± SEM, as indicated in the legend of each figure. The significance of the differences between groups was evaluated using unpaired t test, p value < 0.05 was considered significant. Statistical parameters including the precision

• br Given that CD plays a pivotal role in regulating

  2020-08-30

  

  Given that CD133 plays a pivotal role in regulating cancer metas-tasis and therapeutic resistance and that both of cancer metastasis and drug resistance are the major contributors to cancer death, targeting CD133 in cancer patients who have metastatic disease would be the best strategy to bring do

• br In addition as well as

  2020-08-28

  

  In addition, as well as for membrane potential, there is a differential effect of the co-culture with different fibroblast 1428935-60-7 for ROS. The co-culture with the AF produces a greater increase of ROS in the tumor cells than the co-culture with CF1. On the contrary, the increase of ROS in both

• br B br C br ShamSham

  2020-08-28

  

  B C ShamSham ShamBCF1BCF2BCF3 3000 Blood exosome Sham BCF Sham BCF Sham BCF D TCGA Overallsurvival Time (Months) E Primary Brain- Other- No- Brain- met met met met I HBMEC Control J Sham Numberoftubes/field G Intracellular Exosom

• Rottlerin br J Kremer K Steenstrup Pedersen C Igel Active

  2020-08-18

  

  [18] J. Kremer, K. Steenstrup Pedersen, C. Igel, Active Learning With Support Vec-tor Machines, 4, Wiley Interdisciplinary Reviews: Data Mining and Knowledge Discovery, 2014, pp. 313–326. [21] H. Samet, Foundations of Multidimensional and Metric Data Structures, Else-vier, Amsterdam, 2006. [

• b iframe width height src https www youtube

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  r> METHOD DETAILS Tissue quality control via RNA integrity measurement After homogenization in a MM301 mechanical homogenizer (Retsch, Germany) using a metal ball for 2 3 2 min at 25 s-1 in 600 mL of RLT buffer (QIAGEN, Germany) with 1% b-mercaptoethanol, total RNA was isolated using RNeasy M

• Giralt M Villarroya F Mitochondrial uncoupling

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  Giralt, M., Villarroya, F., 2017. Mitochondrial uncoupling and the regulation of glucose homeostasis. Curr. Diabetes Rev. 13, 386–394. Grippo, P., Maker, A.V., 2017. Targeting cancer with tumor-specific therapeutic strate-gies-metabolic reprogramming beyond the Warburg effect. Transl. Cancer Res. 6,

• br Av treatment increases primary tumor volume

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  3.2.1. Av treatment increases primary tumor volume and does not block metastasis in the xenograft mouse model Av treatment increased the volume of primary tumors of NSG mice xenografted with MDA-MB-231 115144-35-9 (Supplementary Fig. S1). Moreover, Av treatment failed to inhibit metastases of M

• br GSH NADH and NADPH Measurements

  2020-08-18

  

  GSH, NADH and NADPH Measurements Free Heme Measurements Free heme was extracted with neutral acetone as described (Espinas et al., 2012). Heme from neutral acetone extracts was quantified with the Heme assay kit (MAK316-1KT, Sigma-Aldrich), and measurements were normalized to protein concent

• br Conclusions br In conclusion the

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  5. Conclusions In conclusion, the screening barrier most often identified by women was a lack of time (practical barrier) and the screening facilitator most often listed was the low cost of the test. In logistic regression analyses, the number of psychological barriers was related to women's sc

• br of origin which demonstrated similar results

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  of origin, which demonstrated similar results as the original cohort (Table S2). Last, less frequent use of rosuvastatin likely resulted in lack of power to detect the statistical difference as above. A clinical implication of this study is the possible use of a statin to prevent VTE in women w

• br SNPs associated with esophagitis in lung

  2020-08-14

  

   166 SNPs associated with esophagitis in lung cancer Table 3 Multivariate analysis using a Cox regression model with a stepwise backward elimination procedure of factors associated with acute and late esophagitis. Parameter Acute esophagitis Late esophagitis Grade 2 Grade 3

• br MODEL br Introduction br PCa

  2020-08-12

  

  + MODEL Introduction PCa is one of the most common types of cancer expected to occur in all males and accounts for 1 in 5 new diagnoses, excluding lung and bronchus, of the male patients; PCa is the second leading cause of cancer death in men in the United States.1 Cancer metastasis is the p

• br different time intervals The drug release experiments for

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  different time intervals. The drug release experiments for each media were conducted in triplicate. 2.6. Conjugation of HER2 Apt to CCM-loaded HSA NPs The conjugation of HER2-binding Apt to the surface of HSA NPs was achieved via covalent amide bond formation between amine groups of Apt and

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